Point: Early Salvage vs Adjuvant Radiotherapy for High-Risk Prostate Cancer.

Point: Early Salvage vs Adjuvant Radiotherapy for High-Risk Prostate Cancer. - PubMed - NCBI

Counterpoint: Early Salvage vs Adjuvant Radiotherapy for High-Risk Prostate Cancer.

Radical prostatectomy and radiotherapy remain the most popular treatments for localized prostate cancer.[1] In the most recent updated iteration of the Partin Tables, approximately 24% of patients undergoing prostatectomy for clinically localized prostate cancer are predicted to have adverse pathologic findings such as extraprostatic extension (EPE) or seminal vesicle invasion (SVI), and as man...

Reply from Authors re: Ronald C. Chen. Making Individualized Decisions in the Midst of Uncertainties: The Case of Prostate Cancer and Biochemical Recurrence. Eur Urol 2013;64:916–8: Optimal Timing for Postoperative Radiation: Still an Unanswered Question

[2] Trock BJ, Han M, Freedland SJ, et al. Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA2008;299: 2760–9. [3] Stephenson AJ, Shariat SF, Zelefsky MJ, et al. Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy. JAMA 2004; 291:1325–32. [4] Thompson IM, Tangen CM, Parade...

Who, when, where, and how: salvage prostate cancer with radiotherapy.

Despite the common use of postoperative radiotherapy (RT) in patients managed initially with radical prostatectomy (RP), a number of questions remain. Raldow and colleagues build their arguments around three randomized trials that indicated a significant benefit of immediate adjuvant radiotherapy in patients with high-risk features. They acknowledge that routine adjuvant radiotherapy might resu...

Very Early Salvage Radiotherapy Improves Distant Metastasis-Free Survival.

PURPOSE Early salvage radiotherapy following radical prostatectomy for prostate cancer is commonly advocated in place of adjuvant radiotherapy. We aimed to determine the optimal definition of early salvage radiotherapy. MATERIALS AND METHODS We performed a multi-institutional retrospective study of 657 men who underwent salvage radiotherapy between 1986 and 2013. Two comparisons were made to ...